Myocardial protection jacket for topical hypothermia: Reply

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Therapeutic Hypothermia for Myocardial Protection in ST Elevation Myocardial Infarction

Following the return of spontaneous circulation after cardiac arrest, the use of therapeutic hypothermia (TH) has been demonstrated to improve neurologic outcomes and mortality. The potential cardiac benefits and the role of induced hypothermia as a cardioprotective strategy are less clear. Numerous laboratory and clinical studies implicate both inciting myocardial ischemia and subsequent reper...

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SPOTLIGHT REVIEW Myocardial protection with mild hypothermia

Mild hypothermia, 32–358C, is very potent at reducing myocardial infarct size in rabbits, dogs, sheep, pigs, and rats. The benefit is directly related to reduction in normothermic ischaemic time, supporting the relevance of early and rapid cooling. The cardioprotective effect of mild hypothermia is not limited to its recognized reduction of infarct size, but also results in conservation of post...

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Bilateral diaphragmatic paralysis following topical cardiac hypothermia.

Topical cardiac hypothermia has been shown to be a safe and effective means of providing protection for the ischemic myocardium during aortic cross-clamping. We report herein two cases of postoperative bilateral diaphragmatic paralysis which we believe resulted from hypothermic injury to the phrenic nerves. After open-heart surgery, both patients experienced prolonged weaning from assisted vent...

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A simple cooling circuit for topical cardiac hypothermia.

Rapid uniform cooling of the heart is the most important requirement of any method using local hypothermia for protection of the myocardium during open intracardiac surgery. We report the construction and operation of a recirculation cooling circuit comprising a reservoir, pump, and heat-exchanger for this purpose. It is operated by the perfusionist and can deliver up to 1 litre of fluid per mi...

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Myocardial function in severe hypothermia.

GENERALIZED hypothermia, as employed in cardiac surgery,' involves a number of factors, some of which are of benefit, others detrimental to myocardial performance. For example, the decreased arterial pressure and the increased blood viscosity tend to reduce coronary blood flow. On the other hand, the reduced metabolic rate of heart muscle, the diminished cardiac work, and the lengthened time fo...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 1987

ISSN: 0022-5223

DOI: 10.1016/s0022-5223(19)36199-9